This academic article entitled “Quality of Life of Service Business Employees in Epidemic Situation of CLMV countries” is collecting data from the textbooks website theories those are received affected wage per day. Using the Quality of Work Life follow by theory of Richard E. Walton, the result that we collected explained those workers are satisfying their quality of work life in average level. However, they are. When an epidemic occurs the business that is directly affected is the airline business. Tourism and Hotels Employees that will be affected by the drop of tourists there is both unable to use the service as scheduled due to the policies of each country or the fear of the epidemic of tourists themselves, as well as the tourism and hotel businesses that have been predicted by investment experts as the business with the most difficult recovery. They moreover are higher satisfying in the social relevance factor and they are satisfying in the development of human capacities factor, the future opportunity for continued growth and security factor and the total life space factor.